Biochemical Predictors of Chemotherapy-Induced Toxicity: A Prospective Observational Study Evaluating the Role of Serum Albumin, C-Reactive Protein, Neutrophil-to-Lymphocyte Ratio, and Lactate Dehydrogenase

Abstract

This prospective observational study aims to evaluate the role of serum albumin, C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), and lactate dehydrogenase (LDH) as predictive biomarkers for chemotherapy-induced toxicity. A total of 150 patients undergoing chemotherapy were enrolled and followed throughout the treatment cycle. The results indicate that low serum albumin, high CRP, elevated NLR, and increased LDH levels are significantly associated with higher grades of chemotherapy-induced toxicity. These easily accessible and cost-effective biomarkers can be valuable in early identification of high-risk patients and in optimizing chemotherapy management.

Keywords: Chemotherapy, Toxicity, Serum Albumin, C-Reactive Protein, Neutrophil-to-Lymphocyte Ratio, Lactate Dehydrogenase